Suburothelial myofibroblasts in the human overactive bladder and 1 the effect of BoNTA treatment
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منابع مشابه
Cadherin-11 up-regulation in overactive bladder suburothelial myofibroblasts.
PURPOSE We investigated whether the adherens junction proteins cadherin-11 and beta-catenin can be immunohistochemically visualized in the human bladder using commercially available antibodies and, if so, whether there are differences between patients with overactive bladder and refractory detrusor overactivity, and controls without lower urinary tract symptoms. MATERIALS AND METHODS In a pro...
متن کاملCytokine Effects on Gap Junction Communication and Connexin Expression in Human Bladder Smooth Muscle Cells and Suburothelial Myofibroblasts
BACKGROUND The last decade identified cytokines as one group of major local cell signaling molecules related to bladder dysfunction like interstitial cystitis (IC) and overactive bladder syndrome (OAB). Gap junctional intercellular communication (GJIC) is essential for the coordination of normal bladder function and has been found to be altered in bladder dysfunction. Connexin (Cx) 43 and Cx45 ...
متن کاملThe Effect of Electrical Nerve Stimulation in Management of Overactive Bladder in the Pediatric Population; A Systematic Review and Meta-Analysis
Background: In traditional medicine and recent years, nerve stimulation has been introduced as a replacement therapy for managing several disorders such as overactive bladder. However, there is still controversy in this regard. Therefore, the present meta-analysis aimed to assess the effectiveness of electrical nerve stimulation in treatment of overactive bladder.Methods: The present systematic...
متن کاملMuscarinic receptor antagonists, the overactive bladder and efficacy against urinary urgency
The overactive bladder (OAB) is a debilitating condition in which patients suffer from urinary urgency, frequency and nocturia with or without urge urinary incontinence. The mainstay of pharmacotherapy for OAB is muscarinic receptor antagonists, which have been shown to be effective treatments for the symptoms of OAB. The mechanism underlying the efficacy of antimuscarinic agents against the sy...
متن کاملEfficacy of botulinum toxin type A 100 units versus 200 units for treatment of refractory idiopathic overactive bladder
OBJECTIVE To evaluate the efficacy and safety of a single intra detrusor injection of BoNTA comparing two different doses (100 U or 200 U) in patients with idiopathic overactive bladder. MATERIALS AND METHODS A randomized prospective study evaluated the efficacy of BoNTA in management of refractory idiopathic overactive bladder and included 80 patients. All patients were assessed initially by...
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تاریخ انتشار 2008